ESTUDIO WHI, REVISTA DE MENOPAUSIA, SALUD, REVISTAS MÉDICAS. Actualidad Inmediata Debido a la importancia de esta investigación y al impacto en. WHI. Progestin. Estrogen. Tibolone. Cardiovascular disease. Tromboembolic disease . Boletín de la Asociación Española para el Estudio de la Menopausia, . Los trastornos de la menopausia pueden ser evitados y combatidos Sin embargo, recientes estudios, como el estudio WHI, han puesto en duda los beneficios.

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WHIMS-Y provided an unprecedented chance to examine the hypothesis that HT may have protective effects on cognition in younger postmenopausal women aged 50—54 years.

J Clin Endocrinol Metab, 89pp. The effect of a soy rich diet on the vaginal epithelium in postmenopause: Differences in effects between cognitive domains suggest that more than one mechanism may be involved.

Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk. Risks and benefits of estrogen plus progestin in healthy postmenopausal women.


Int J Cancer,pp. Maturitas, 45pp. The Management of the Menopause. As well known, the relevant overall WHI Memory Study WHIMS results were very disappointing, showing some increased risk for cognitive impairments and for development of dementia in the hormone users, when compared to the placebo arm.

Hum Reprod, 16pp.

These cancers were invasive. Failure of estrogen plus progestin therapy for prevention. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes.

Changes in symptoms, lipid and hormone levels after the administration of a cream with phytoestrogens in the climateric: Serum enterolactone concentration is not associated with breast cancer risk in a nested casecontrol study.


Although there are no results yet from this ongoing study, it already carries an important message.

Dietary soy has both beneficial and potencially adverse cardiovascular effects: Are you a health professional able to prescribe or dispense drugs? National Institutes of Health, Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: Clin Invest Gin Obst, 30pp.

The effect of isoflavones extracted from red clover Rimostil on lipid and baile metabolism. Indeed, the study demonstrated a significant smaller coronary calcium score a lower calcified-plaque burden in women who used estrogen during the WHI trial as compared to those who were allocated to the placebo arm [8].

Role of the gut flora in toxicity and cancer, pp. It demonstrates a post-factum change in perceptions about the potential effects of HT on cognitive brain function and brain aging.

Results from WHI and HERS II – Implications for women and the prescriber of HRT

Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. WHI does not introduce new rules to good clinical practice. J Clin Endocrinol Metab, 86pp. Fertil Steril, 77pp. The Wh safety committee [ 1 and 2 ] decided to interrupt one arm of the study because women on the combined estrogen-progestin, at the end 5.

Mammalian lignans and phytoestrogens. Maturitas, 42pp.

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High quality observational studies may extend evidence over a wider population and are likely to be dominant in the identification of harms [ 8 ]. Cancer Epidemiol Biom Prev, 11pp. A review of the clinical effects of phytoestrogens. Influence of estrogen plus progestin on breast cancer and mammography in healty postmenopausal women.


Br J Nutr, 89pp. During the trial women in the estrogen plus progestin group and in the placebo group had an hysterectomy [ 1 ].

The authors raised two important questions that need attention. Intern J Cancer, 81pp. Furberg CD, et al. Strengths of Esthdio include balance in baseline risk factors between treatment groups, standardized and masked data collection, and high rates of retention and on-trial adherence and exposure.

JAMA,pp. In the protocol of the study it is mentioned that women mejopausia to have a base line mammography [ 5 ].

Hu FB, Grodstein F, et al. The second was whether hormone use by younger postmenopausal women near the time of menopause reduces dementia risk or whether WHIMS findings should be generalized to younger women. The effects of soy-derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women.

Risk and benefits of estrogen plus progestin in healty postmenopausal women. The estrogen-alone data were published in and were summarized once again in two separate papers [4,5]: Clin Invest Gin Obst. First came the results from the estrogen plus progestin arm [2,3], which were summarized by the investigators as follows:

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