Jurányi Zsolt is the author of Az alvilág zsoldjában ( avg rating, 16 ratings, 1 review, published ) and Az alvilág csapdájában ( avg rating. nov. Az alvilág csapdájában has 3 ratings and 1 review. Sándor said: Az első rész fényévekkel jobb volt, szerintem. Csak azért vergődtem végig. List of computer science publications by Zsolt Jurányi.

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Jurányi Zsolt

Our data indicate that coadministration of an antipsychotic with a GlyT-1 inhibitor may normalize hypofunctional NMDA receptor-mediated glutamatergic neurotransmission with reduced dopaminergic side effects characteristic for antipsychotic medication. Org injection reduced extracellular dopamine concentrations and elevated extracellular glycine levels but the concentrations of serine and glutamate were not changed.

AB – The most dominant hypotheses for the pathogenesis of schizophrenia have focused primarily upon hyperfunctional dopaminergic and hypofunctional glutamatergic neurotransmission in the central nervous system. T1 – Alterations in brain extracellular dopamine and glycine levels following combined administration of the glycine transporter type-1 inhibitor Org and risperidone.

The therapeutic efficacy of all atypical antipsychotics is explained in part by antagonism of the dopaminergic neurotransmission, mainly by blockade of D 2 dopamine receptors. Neurochemical Research35 12 N2 – The most dominant hypotheses for the pathogenesis of schizophrenia have focused primarily upon jjranyi dopaminergic and hypofunctional glutamatergic neurotransmission in the central nervous system.

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Abstract The most dominant hypotheses for the pathogenesis of schizophrenia have focused primarily upon hyperfunctional dopaminergic and hypofunctional glutamatergic neurotransmission in the central nervous system.

Keywords Antipsychotic agents Extracellular glycine and dopamine Glycine transporter type-1 inhibitors Microdialysis Schizophrenia.

N-methyl-d-aspartate NMDA receptor hypofunction in schizophrenia can be reversed by glycine transporter type-1 GlyT-1 inhibitors, which regulate glycine concentrations at the vicinity of NMDA receptors. The most dominant hypotheses for the pathogenesis of schizophrenia have focused primarily upon hyperfunctional dopaminergic and hypofunctional glutamatergic neurotransmission in the central nervous system. When risperidone and Org were added in combination, a decrease in extracellular dopamine concentrations was accompanied with sustained elevation of extracellular glycine levels.

The therapeutic efficacy of all atypical antipsychotics is explained in part by antagonism of the dopaminergic neurotransmission, mainly by blockade of D2 dopamine receptors. Risperidone increased extracellular concentrations of dopamine but failed to influence those of glycine or glutamate measured in microdialysis samples. Access to Document Link to publication in Scopus. Interestingly, the extracellular concentrations of glutamate were also enhanced.

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dblp: Zsolt Jurányi

To investigate this type of combined drug administration, rats were juranyk with the atypical antipsychotic risperidone together with the GlyT-1 inhibitor Org Alterations in brain extracellular dopamine and glycine levels following combined administration of the glycine transporter type-1 inhibitor Org and risperidone. Combined drug administration with D 2 dopamine receptor blockade and activation of hypofunctional NMDA receptors may be needed for a more effective treatment of positive and negative symptoms and the accompanied cognitive deficit in schizophrenia.

Neurochemical ResearchVol. Link to citation list in Scopus.

Combined drug administration with D2 dopamine receptor blockade and activation of hypofunctional NMDA receptors may be needed for a more effective treatment of positive and negative symptoms and the accompanied cognitive deficit in schizophrenia.

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